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NJBMS - Volume 1, Issue 3, January - March 2011

Pages: 154-157

COMPARISON OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF ASPARAGUS RACEMOSUS WITH ASPIRIN

Author: Maharani.B, Meher ali.R .

Category: Pharmacology

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Abstract:

Objectives:

To Compare Analgesic and Anti-inflammatory activity of Ethanolic Extract of Asparagus racemosus with Aspirin.

Materials andMethods:

Analgesic method – 18 Albino mice of either sexweighing about 20-25gmwere randomly divided in to 3 groups of 6 animals each. The control group, Standard and test group were given distilled water, Aspirin (100mg/kg) and Ethanolic extract of Asparagus racemosus (200mg/kg) respectively. Drugs were given orally after overnight fasting. Analgesic activity is evaluated before drug administration, after 2 hrs and 4 hrs of drug administration by Tail clip method. A wash out period of 15 days is given and the same group was utilized for evaluation of analgesic activity by hot platemethod. Anti-inflammatory activity – 18 Albino rats of either sex weighing about 175-225 gm were randomly divided in to 3 groups of 6 animals each. The control group, Standard and test group were given distilled water, Aspirin (300mg/kg) and Ethanolic extract of Asparagus racemosus (1600mg/kg) respectively. Drugs were given orally after overnight fasting. Anti-inflammatory activity is evaluated by measuring foot paw volume by using plethysmograph before administration of 1% carrageenan and 3 hrs after drug and 1% carrageenan administration.

Results:

The observations from Analgesic activity of the extract showed, the mean reaction time(In Tail clip and Hot plate method) in the test group after 2nd and 4th hour of drug administration was statistically significant (P< 0.01,P< 0.001) and it was comparable with Aspirin. Observations from Anti-inflammatory activity of the extract showed, there was 61.11% of inhibition of edema in the test group and itwas comparable with the standard which had 69.45% of inhibition of edema.

Conclusions:

Ethanolic extract of Asparagus racemosus has analgesic and anti-inflammatory activity which was comparable with Aspirin.

Keywords: Plethysmograph, Carrageenan, Asparagusracemosus

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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