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NJBMS - Volume 1, Issue 1, July - September 2010

Pages: 15-21

EFFECT OF SHORT TERM INSULIN REGIMEN ON LIPID PEROXIDATION IN TYPE-2 DIABETES MELLITUS.

Author: P.K.MOHANTY, BHAVANA BAI

Category: Biochemistry

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Abstract:

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and insufficiency of either secretion or action of endogenous Insulin. The disease is better known for its complications affecting the vascular system , kidney, retina, lens, peripheral nerves and skin, which are extremely costly in terms of longevity and quality of life. Increased oxidative stress is an widely accepted contributing factor towards development and progression of diabetes and its complications. Diabetes is usually accompanied by increased production of free radicals or reactive oxygen species (ROS) and impaired anti oxidant defenses that leads to damage of all bio-molecules like lipids, proteins, carbohydrates, DNA etc. and initiation of micro and macro vascular complications. MDA (Malondialdehyde) is used as an index of oxidative damage and has the ability to interact with lipoproteins. The present study examines the extent of oxidative damage and alteration of lipid profile in 60 NIDDM cases and 25 age and gender matched control subjects. It is observed that diabetics reveal increased oxidative damage as reflected by their higher MDA level in comparison to normal controls(5.30±2.8 vs 4.6±0.83). Among the diabetics hypercholesterolemia (21%), Triglyceridemia(48.3%) and higher BMI (66.6% > 22.9)are frequent. The study reveals that patients on short term insulin regime show considerably low levels of MDA(3.41±1.4 mmol./L), lowered serum triglycerides(143±99) and eventually a better lipid profile as compared to cases on oral hypoglycemic agents and cases adhering to other regimes for glycemic control. Therefore short term insulin regimen should often be recommended to NIDDM cases not only as an efficient means of glycemic control, but as an active agent for improving anti-oxidant defense status and reducing lipid per-oxidation. In conclusion short term insulin regimen is advocated for long term health benefits in NIDDM.

Keywords: Diabetes mellitus

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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