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NJBMS - Volume 4, Issue 4, April - June 2014

Pages: 201-205

SERUM PARAOXONASE ACTIVITY IN CHRONIC KIDNEY DISEASE

Author: K. GEETHA, K. PRAMILA, K. CHELLADURAI

Category: Biochemistry

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Abstract:

Background: Kidney disease is both a cause and consequence of Cardiovascular Vascular Disease(CVD) which is the leading cause of morbidity and mortality. Chronic Kidney Disease (CKD) is a chronic inflammatory state which is associated with uremia induced atherogenic alterations in addition to complex dyslipidemia consisting of both qualitative and quantitative abnormalities in serum lipoproteins. Activity of Paraoxonase (PON), a high density lipoprotein associated molecule with antioxidant and antiatherogenic function is decreased in CKD patients contributing to CVD.

Aim : The aim of this study is to analyze the Serum PON activity and Lipid profile in CKD patients for predicting the atherogenic risk in these patients.

Materials and Methods : The study population classified into two groups : Consisting of 50 healthy subjects & 50 CKD patients excluding liver disease, chronic infections and Diabetes Mellitus. The PON activity and lipid profile were estimated and compared by Student ‘t’ – test between the two groups.

Results : The mean value of the Serum PON activity in the cases (46.47 + 24.45 U/L) showed a significant fall of 60.4% compared to the mean value of the controls (117.38 ± 30.62 U/L); p< 0.001 and there is a significant decrease in PON activity in CKD patients..The differences in the lipid profile were associated with the secondary dyslipidemic changes in CKD.

Conclusion: There is a significant decrease in PON activity in CKD patients and thus decreasing its anti atherogenic function which could be an important factor in premature vascular aging. Uremia induced atherogenic alterations probably start to take place much earlier in the course of CKD.

Keywords: Cardiovascular disease, Chronic kidney disease, High density lipoprotein, Low density lipoprotein, Paraoxonase

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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