UA-22728437-71


NJBMS - Volume 4, Issue 4, April - June 2014

Pages: 234-238

COMPARATIVE EVALUATION OF EFFICACY AND TOLERABILITY OF AZITHROMYCIN AND CLINDAMYCIN GEL IN MILD TO MODERATE ACNE VULGARIS

Author: SMITHA RAI, T.N. KUMAR, RAJENDRA OKADE

Category: Pharmacology

[Download PDF]

Abstract:

Background ; Topical antibotics are preferred for treatment of mild to moderate acne vulguris. As there was the lack of studies comparing azithromycin 2% gel and clindamycin 1% gel in acne vulgaris, this study was teken up.

Materials and Methods : A prospective study was conducted in which patients with mild to moderate acne vulgaris were enrolled. Relevant information on each patient was collected according to the proforma. Patients were advised to apply the test medication over the face, once daily at bedtime. They were followed up every 2weeks, until 8 weeks. At each visit, efficacy of the test medication was assessed by lesion count, Global Clinical Evaluation (GCE), and Patient’s Self-assessment (PSA). Safety of the medications was assessed by Investigator Rated Patient’s Tolerability (IRPT) and adverse effects.

Results : In our study,most of the patients were aged < 20 years and were females. The malar region was the most common site of involvement. Patients receiving azithromycin 2% gel and clindamycin 1% gel showed significant improvement with respect to lesion count, GCE, and PSA. The difference in the improvement in the above paratmeters was found to be statistically insignificant between the two groups. Both the medications were found to be equally safe with the pruritus being more common with azithromycin and burning sensation with clindamycin.

Conclusion : Both azithromycin 2% gel and clindamycin 1% gel are equally efficacious and safe in mild to moderate acne vulgaris.

Keywords: Acne vulgaris, Azithromycin, Clindamycin gel.

No. of online users: 6

Search Articles



Visitor Counter

World wide visitors

News

Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


Indexed in

Index Copernicus (MCI recognized indexing body) ICV - 75.97, Scientific Indexing Services, Research Bib, Indian Science Publication, Eurasian Scientific Journal Index, Science Library Index, International Innovative Journal Impact Factor, Cite Factor, International Impact Factor Service,

Publication Statistics

Articles Statistics

Advertisements

Society for Basic Medical Sciences
NJBMS Journal - Indexed in Index Copernicus

Manuscript Statistics

Subscribe for TOC Alerts

Get the table of contents of current issues.

E-mail Alerts