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NJBMS - Volume 4, Issue 3, January - March 2014

Pages: 151-154

ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM (G894T) IN ESSENTIAL HYPERTENSION

Author: V. RAJAGOPAL, D. PONNUDHALI, RITA MARY ARUNA, EVANGELINE JONES

Category: Biochemistry

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Abstract:

Background: Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. The single nucleotide polymorphism (G894T) in exon 7 of human eNOS gene has been found to be associated with the development of essential hypertension in different ethnic populations.

Aim and Objectives: (a) The aim is to assess the G894T polymorphism of eNOS gene in patients with essential hypertension in a rural population of Salem, Tamil Nadu. (b) Also to determine the genotype and mutant allele (‘T’) frequency in them.

Materials and Methods: Polymerase chain reaction and restriction fragment analysis was done to detect the presence of (G894T) variant of the eNOS gene in 41 hypertensive patients.

Results: The frequency of the eNOS GG, GT, and TT genotypes was found to be 88%, 12%, and 0% respectively. The frequency of mutant (T) allele was found to be only 6.1%.

Conclusion: The occurrence of homozygous wild G/G genotype is predominant and the homozygous mutant T/T genotype was not seen in the representative hypertensive subjects of our population in Salem. The presence of mutant(T) allele among the studied population was less common.

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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