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NJBMS - Volume 4, Issue 3, January - March 2014

Pages: 163-168

STUDY OF ATHEROSCLEROSIS IN RURAL INDIA USING MODIFIED AMERICAN HEART ASSOCIATION CLASSIFICATION WITH SPECIFIC REFERENCE TO YOUNG ADULTS

Author: R. KALYANI, M.J. THEJ, J. KIRAN

Category: Clinical Sciences

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Abstract:

Objective: Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary artery disease. Currently Indians experience cardiovascular deaths at least a decade earlier than their counterparts in developed countries.

Materials and Methods: The study was conducted on 113 hearts and aorta of patients who had died of nonvascular causes of which 52 were between the age group of 15‑34 years. Microscopic examination of atherosclerosis in the coronary arteries and aorta was done using the modified American Heart Association classification. Proportions were analyzed using Chi‑square test.

Results: Thirty three (63.5%) were males and 19 (36.5%) were females. In males, 16.51% of the coronaries showed advanced lesions, 44.54% showed raised lesions and in Aorta 23.01% showed advanced lesions and 62.54% showed raised lesions. Among females, 9.73% of the coronaries showed advanced lesions and 28.91% showed raised lesions. In Aorta 16.37% showed advanced lesions and 66.66% showed raised lesions. Three arteries showed erosion and small thrombus in the background of pathological intimal thickening. Moderate and severe inflammation was noted in thick and thin fibrous cap atheroma respectively.

Conclusion: Hence the incidence of atherosclerosis in young individuals is high in present study which suggests requirement of preventive measures.

Keywords: Atherosclerosis, Autopsy, Young adults

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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