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NJBMS - Volume 4, Issue 2, October - December 2013

Pages: 101-106

A COMPARATIVE STUDY OF ARTERIAL STIFFNESS INDICES BETWEEN SUBJECTS WITH POSITIVE AND NEGATIVE FAMILY HISTORY OF HYPERTENSION

Author: VIJAYALAKSHMI .I, ASHOK .J, SHANKARAPPA. V, SIVAGAMI. G

Category: Physiology

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Abstract:

BACKGROUND: Family history of hypertension is one of the primary predictor of high blood pressure (BP). Family history represents the integration of shared genomic and environmental risk factors. This suggests that early detection of arterial changes for those at risk might be a practical and useful way to target interventions and disease prevention.

AIM: To find out the trend in increase of blood pressure and early changes in arterial elasticity in young individuals with family history of hypertension.

METHOD: A total of 100 normotensive healthy individuals (aged 20 to 30 years, both gender) were divided into two groups. Group I (50 subjects) with a family history of hypertension and group II (50 subjects) without a family history of hypertension. After a detailed history, the subject's anthropometric and blood pressures were measured. Both the groups underwent arterial stiffness index measurement with the help of finger photo pulse plethysmography.

RESULT: There were no significant differences in both the groups in regard to systolic and diastolic blood pressure. However when arterial stiffness index and reflection index were analyzed, p value was significant in group I subjects (p=< 0.000). The results were statistically analyzed by using SPSS Software version 17.0 .

CONCLUSION: In comparison with group II controls, normotensive offspring of hypertensive parents had slight increase in BP and impaired arterial properties, namely large and small arterial compliance. Alteration in arterial function in young non-hypertensive subjects may be a risk factor for hypertension and may contribute to the progression to hypertension in later life.

Keywords: positive family history of hypertension, finger photo pulse plethysmography, arterial stiffness index, reflection index.

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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