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NJBMS - Volume 4, Issue 1, July - September 2013

Pages: 62-64

THE STUDY OF EFFICACY OF NIMODIPINE IN POTENTIATION OF THE ANAESTHETIC EFFECT OF KETAMINE IN GUINEA PIGS

Author: TAMILARASI.S, ABDUL RAHMAN A, PARAMESWARI R

Category: Pharmacology

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Abstract:

Objectives : To investigate whether nimodipine potentiates theanaestheticeffectofketamine, inguineapigs.

Materials and Methods : 18 adult male guinea pigs of weight 400-600 grams were utilized. They were randomly divided into three groups of 6 each. First group received only Injection. Nimodipine 10 mg/kg intraperitoneally. Second group received only Inj.Ketamine 50 mg/kg i.p. Third group received Inj.Nimodipine 10 mg/kg, 30 minutes before Inj.Ketamine 50mg/kg i.p. After administration of the drug, animals are watched for its righting reflex. Induction time is the time duration from administration of the drug till the animal loses its righting reflex is noted. The duration of anesthesia(time duration from the animal loses its righting reflex till it regains the same) were noted in each group. The observations are analyzed with suitable statistical tool.

Results : Ketamine has got anesthetic effect and when nimodipine is administered along with ketamine, it has significantly potentiated the anaesthetic effect of ketamine (P< 0.05) compared to ketamine alone. Nimodipine has got no anaesthetic effect.

Conclusion : This study suggests that nimodipine, potentiates the anaesthetic effect of ketamine, hence nimodipine, could be a potential adjunct to ketamine, achieving a therapeutic effect at a lower concentrations of ketamine, hence limiting their dose related toxicities, which needs to be explored further.

Keywords: Ketamine, Nimodipine, Anesthetic effect, Induction Time, Righting reflex.

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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