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NJBMS - Volume 6, Issue 3, January - March 2016

Pages: 106-112

SERUM GAMMA GLUTAMYLTRANSFERASE AND THE RISK OF STROKE IN CHRONIC EXCESS ALCOHOLISM

Author: K. CHELLADURAI, R.SURESH

Category: Biochemistry

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Abstract:

Background : Stroke continues to be the major public health problem. It ranks in the top four causes of death in most countries and is responsible for the large proportion of neurological disorders. More often disabling than fatal stroke is the leading cause of severe neurological disability. It results in enormous costs measured in both health-care expenses and lost productivity which is vital for a nation especially India where 12 percent of stroke cases are below 40 years of age (stroke in the young) with a case fatality rate of 1 percent.

Aim and Objective: The aim is to analyze serum gamma glutamyltransferase (GGT) activity and Low Density Lipoprotein (LDL) concentration to achieve the objective of predicting the risk factors for stroke in chronic excess alcoholism.

Materials and Methods: This is an age and sex matched comparative study. The study population includes two groups; group 1 consists of 50 persons with self- reported, chronic, regular excess alcohol intake (greater than 400g per week which approximately equal to 1400ml of brandy per week or just 200 ml per day) ; group 2 consists of stroke patients who have been taking alcohol similarly. Serum GGT and LDL were estimated and compared by Student's t-test and Pearson's correlations between the two groups.

Results: The mean value of serum GGT and LDL were significantly increased in cases compared to the controls with p value 0.001 (GGT) and 0.021 (LDL).

Conclusion: Chronic alcoholism increases the risk of stroke. Self-reporting of alcohol drinking under-estimates the true risk. Thus the use of GGT- the biological marker of alcohol drinking is a helpful tool for risk assessment. Excessive intake of alcohol, raised GGT level and increased LDL-cholesterol compound the risk for stroke.

Keywords: Alcohol, Stroke, Cerebrovascular disease, Gamma glutamyltransferase, Low density lipoprotein.

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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