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NJBMS - Volume 6, Issue 1, July - September 2015

Pages: 6-10

ASSOCIATION OF SERUM LIPID PROFILE, BODY MASS INDEX AND ATHEROGENIC INDEX WITH COGNITIVE FUNCTIONS IN POSTMENOPAUSAL WOMEN

Author: R..KAVITHA, R. SUDHA, EVANGELINE JONES

Category: Biochemistry

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Abstract:

Background: Cognitive dysfunction has increased in menopausal women, which indicate the initiation of dementia. Body mass index (BMI) have been shown to influence brain development in relationship to early and late measures of cognitive function. A strong interaction between brain areas is involved in cognitive, emotional, and metabolic regula- tory functions controlling body weight.

Aim: To assess serum lipid profile, BMI, atherogenic index of plasma (AIP) and cognitive functions in postmenopausal women and to correlate the serum lipid profile, BMI, AIP with cognitive functions in postmenopausal women.

Methodology: A cross-sectional study was carried out with 40 premenopausal and 40 postmenopausal at the gynecological outpatient department of Vinayaka Missions Kirupananda Variyar Medical College, Salem. For all the study subjects, the lipid parameters were measured using the standard kits and the cognitive assessment was done by Addenbrooke’s cognitive examination (ACE) - ACE-revised (ACE-R). ACE and its revised version (ACE-R) which includes five domains for assessing the mini mental status.

Results: The BMI, total cholesterol, low-density lipoprotein, triglycerides and AIP were significantly a higher among the post-menopausal women when compared to the premenopausal women (P < 0.05). Similarly, the high-density lipoprotein levels were lower in the study group when compared to the control group. All the cognitive parameters including the ACE-R total and the mini mental scale examination score were comparatively higher in the premenopausal women than the post-menopausal and the difference was found to be statistically significant (P < 0.05).

Conclusion: Altered lipid levels have a definite asso- ciation with decreased cognitive abilities in postmenopausal women. Interventions to lower the lipid levels may be a potential strategy for prevention of cognitive impairment.

Keywords: Atherogenic index, Body mass index, Cognitive function, Post-menopausal women

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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