NJBMS - Volume 3, Issue 2, October - December 2012

Pages: 109-113



Category: Physiology

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Background: The altered serum levels of triiodothyronine (T3) and thyroxine(T4) in thyroid disorders is well established but the correlation of CPK (Creatine Phospho Kinase) with thyroid dysfunction is not.

Aims and objectives: To confirm definite changes in CPK levels alter functions of thyroid gland and establish serum CPK level estimation as a valid indicator of thyroid dysfunction; and suggest it as a screening test to differentiate hyper/hypothyroid myopathies.

Materials and methods: Fifty hyper/ hypothroid female patients (from reproductive age group) in a Thyroid Clinic (July-December, 2005) were selected. Fifty controls matching in age/sex were also included. Parameters studied include BMI, serum CPK (Autozyme UV kinetic method), serum T3, T4, TSH (RIA), serum cholesterol, FBS and PPBS.

Results and analysis: Statistical analysis was done using SPSS Windows version 10 and association among the variables were assessed using Pearson Chisquare test. In hypothyroid patients, T3/T4 serum levels were found lowered with increased TSH levels(100%) along with marked rise in CPK levels(84%) whereas hyperthyroid cases showed an increase(T3/T4 serum levels) with decrease in TSH( 96%) and CPK levels; and thus confirming, an inverse relation between Serum CPK levels and T3/T4 levels.

Conclusion: Hypothyroidism reduces ability of muscles to maintain its energetic economy leading to myopathy causing elevation of CPK levels while a decrease in the generation of enzyme is the cause in hyperthyroidism. Thus myopathy may be the sole clinical manifestation in altered thyroid states suggesting that all patients with unexplained muscular symptoms should be screened for thyroid dysfunction with serum CPK.

Keywords: Creatine Phospho Kinase, Thyroid dsfunction, Myopathies.

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.

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