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NJBMS - Volume 3, Issue 2, October - December 2012

Pages: 130-133

VARIATIONS IN LEVELS OF GAMMA GLUTAMYL TRANSFERASE AND GLUTATHIONE PEROXIDASE DURING PREGNANCY ADVANCEMENT AND PREECLAMPSIA

Author: JAYASHREE P. ANDHARE, MADHUR M GUPTA, MANJU S CHANDANKHEDE, SHEELA JAIN

Category: Physiology

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Abstract:

Background : Oxidative stress is known to be a key factor associated with preeclampsia. Glutathione Peroxidase(GPx), an antioxidant enzyme along with cellular γ -Glutamyl transferase (GGT) is responsible for protecting cells from damage due to free radicals like hydrogen and lipid peroxides.

Aim : To assess prooxidant and antioxidant GGT and GPx in pregnancy and preeclampsia.

Design : A case control study.

Material and methods: Estimation of malondialdehyde, GGT and GPx level in blood was carried out by chemical and enzymatic kit method in 20 non-pregnant women as controls, 20 pregnant women in first week of each trimester and 20 preeclampsia patients.

Statistical analysis: Done by `t` test.

Results and conclusion: Serum GGT though not significant increased in first trimester was found to be towards the upper limit of normal range in pregnant women and raised above normal in preeclampsia patients(p< 0.01). GPx level decreased with progression of pregnancy (p value < 0.01) and was found to be decreased in preeclamptic patients. Whether these changes can prove the utility of antioxidants in early pregnancy for the development of preeclampsia needs to be assessed.

Keywords: Preeclampsia, Oxidative stress, Glutathione Peroxidase, Gamma glutamyl transferase, Antioxidant

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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