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NJBMS - Volume 3, Issue 2, October - December 2012

Pages: 154-158

ANTIBIOTIC SUSCEPTIBILITY PATTERN OF BACTERIAL ISOLATES CAUSING SURGICAL SITE INFECTION

Author: NEELESH R NAIK, N. K. RAMA, SHARADADEVI MANNUR. Y, B.V. RENUSHRI, E.R. NAGARAJ

Category: Microbiology

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Abstract:

Background and objectives: Surgical site infections (SSI) constitute about one fourth of all nosocomial infections. Hence this study was carried out to isolate and identify the bacteria causing surgical site infections and to determine their antibiotic sensitivity pattern.

Methods: A total of 204 clinically diagnosed cases of surgical site infections were taken for the study. Antibiotic sensitivity pattern of the isolates was determined. Isolates of Staphylococcus aureus were screened for methicillin resistance by cefoxitin disc diffusion test and were confirmed by minimum inhibitory concentration (MIC) determination using oxacillin E-test. Extended spectrum beta lactamase (ESBL) production wastestedin Escherichia coli and Klebsiellapneumoniae.

Results: The most frequent isolate in our study was Staphylococcus aureus followed by Pseudomonas aeruginosa. Most of the Gram negative organisms were sensitive to piperacillin/tazobactam, ceftazidime and amikacin and all of them were sensitive to imipenem. Gram positive organisms were found to be more sensitive to gentamicin, clindamycin and linezolid. Sensitivity to vancomycin was seen in all the Gram positive isolates. 12 (22.2%) strains of Staphylococcus aureus were methicillin resistant by cefoxitin disc diffusion test and by oxacillin E- test. ESBL production was seen among 25% and 22.22% isolates of Klebsiella pneumoniae and Escherichia coli respectively.

Interpretation and conclusion: Common organisms causing surgical site infections show resistance to various antibiotics, a major problem being the occurrence of methicillin resistant Staphylococcus aureus (MRSA) and ESBL producing Escherichia coli and Klebsiella pneumoniae. Hence it is important to test for the presence of these organisms and treat appropriately.

Keywords: Extended spectrum beta lactamase - methicillin resistant Staphylococcus aureus - surgical site infection

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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