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NJBMS - Volume 3, Issue 2, October - December 2012

Pages: 168-170

SERUM ADENOSINE DEAMINASE, URICACID AND MALONDIALDEHYDE LEVELS IN RHEUMATOID ARTHRITIS

Author: P. SANGEETHA, N. VIJAYABANU, D. PONNUDHALI, EVANGELINE JONES

Category: Biochemistry

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Abstract:

Background: Rheumatoid arthritis (RA) is characterized by inflammation of synovial membrane and oxidative stress has been implicated as mediators of tissue damage. Adenosine deaminase plays an important role in inflammation and uric acid, an endogenous antioxidant has free radical scavenging capacity.

Aims and objectives: 1. To estimate the level of ADA in rheumatoid arthritis patients. 2.To assess the lipid peroxidation product (MDA) & antioxidant status (uric acid) in RA.

Materials and Methods: The study group included a total of 60 subjects of which 30 were RA patients and 30 were healthy controls. Serum ADA, uric acid and MDA levels were analysed. Statistical analysis was performed using independent't'test.

Results: Serum ADA (p< 0.05) and MDA (p< 0.01) levels were found to be significantly high in rheumatoid arthritis patients when compared to controls. No significant difference was observed in uric acid level in both groups.

Conclusion: These data suggest that increased serum ADA indicates inflammation and increased MDA indicates oxidative stress in rheumatoid arthritis.

Keywords: Rheumatoid arthritis, Adenosine deaminase, Reactive oxygen species, Uric acid, Inflammation.

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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