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NJBMS - Volume 3, Issue 3, January - March 2013

Pages: 187-191

LIPID PROFILE AND VARIATIONS IN WBC COUNT AND ESR IN ACUTE MYOCARDIAL INFARCTION

Author: DEEPA G, VIJAYALAKSHMY.R

Category: Physiology

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Abstract:

Background: The incidence of acute myocardial infarction, an important manifestation of coronary artery disease, is very high in India. Dyslipidemia and inflammation are equally important in the process of atherosclerosis, leading to myocardial infarction.

Aims and objectives: The aim is to assess the influence of dyslipidemia in causing myocardial infarction by estimating the fasting lipid profile. The atherogenic index can be assessed by calculating LDL/HDL ratio. The estimation of total white blood cell count (WBC count) and erythrocyte sedimentation rate (ESR) seem to have a definite predictive value for the evidence of inflammation in acute myocardial infarction.

Materials and methods: 60 male patients of 40 - 65 years age, admitted with a diagnosis of acute myocardial infarction, during the period August -- November, 2004 were included in the study. They were compared with 62 healthy male subjects of the same age group, who had no history of coronary heart disease in the past.

Results: Serum total cholesterol, triglycerides, LDL, VLDL and LDL/HDL ratio showed statistically significant increase and HDL showed a statistically significant decrease in myocardial infarction. Both WBC count and ESR showed a significant increase in acute myocardial infarction.

Conclusions: Hyperlipidemia and inflammation definitely influences the occurrence of myocardial infarction. One of the novel findings in the present study was that hypertriglyceridemia puts middle-aged and old-aged men at increased risk for cardiovascular disease regardless of their HDL-cholesterol or LDL- cholesterol levels. Leucocytosis is significantly associated with acute myocardial infarction and is aweak, but independent laboratory predictor of this condition.

Keywords: myocardial infarction, lipoproteins, atherosclerosis, inflammation,

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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