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NJBMS - Volume 3, Issue 3, January - March 2013

Pages: 216-220

HER-2/NEU OVEREXPRESSION IN GASTRIC ADENOCARCINOMA - AN EXPERIENCE AT TERTIARY CARE CENTRE

Author: B.V. MADHAVI, B. RAVI SHANKAR, B. SRIDHAR REDDY, CH. BALAJI, A. BHAGYA LAKSHMI

Category: Pathology

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Abstract:

HER-2 / neu over expression in gastric adenocarcinoma is a negative prognostic factor, ranging in expression between 6-35%.The purpose of the study is to analyse the over ex pression of HER-2/neu i n G astric adenocarcinoma by IHC and confirmation by FISH. This is an analytical study from July 2008 to June 2010 in the department of pathology at a tertiary care centre. In forty two cases with diagnosis of gastric adenocarcinoma, HER -2/neu over expression was scored on IHC. Cases with HER-2/neu expression of 3+ and 2+ cases were subjected to FISH. Out of 42 cases, 36 cases showed negative HER- 2/neu expression. Two cases with IHC score of 3+ had shown amplification on FISH and 4 cases with 2+ score did not show any amplification. In the present study HER- 2/neu over expression was seen in 5% of gastric adenocarcinoma. All cases with IHC score 3+ showed HER-2/neu amplification on FISH.

Keywords: Gastric adenocarcinoma, HER-2/neu, Immunohistochemistry (IHC), Fluorescence in situ Hybridization (FISH).

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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