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NJBMS - Volume 3, Issue 3, January - March 2013

Pages: 227-230

HOSPITALIZATION CAUSED BY ADVERSE DRUG REACTIONS(ADRS) IN A TERTIARY CARE HOSPITAL IN SOUTH INDIA:A RETROSPECTIVE STUDY

Author: JAMUNA RANI.R, PRIYA.M

Category: Pharmacology

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Abstract:

Background: Adverse drug reactions (ADRs) are inevitable consequence of Pharmacotherapy. ADRs have been creating headlines over the last fifty years since the thalidomide tragedy. If we believe that the first principle in treating patients is 'primum non nocere' i.e., 'above all do no harm' weshould beaware of the possibility of ADRs.

Objective: To assess the nature, incidence, severity, causality and preventability of adverse drug events in a tertiary care hospital.

Materials and Methods: Patients presenting to the hospital with an adverse event due to medications were included in the study. Data on such adverse events collected for the year 2010-2011 were analyzed.

Results: The number of hospital admissions due to ADR was 23. Of these 10 were male, 13 were female. Elderly age group comprised of 30.4 %. Nearly 47.87 % of patients have taken these medicines as over the counter,17.1 % of patients presented with severe life threatening reactions and 52.1% of patients seek hospital admissions >5-20 days which is statistically significant. More frequently implicated drugs causing ADRs were Antibiotics (47.8%) in which 36.3% allergic reactions were due to ofloxacin, followed by NSAIDs (39.1%) &the remaining adverse reactions were due to Anti Epileptics & hormonal drug.

Conclusions : The need for ADR monitoring in India is urgent in view of under reported Indian data, the genetic diversity of the Indian population and the many other factors that influence drug use behavior in the country. Prospective studies of similar nature could further help us to assess the burden of adverse drug reactions in patients and to develop better preventive measures.

Keywords: Adverse drug reactions

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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