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NJBMS - Volume 7, Issue 1, July - September 2016

Pages: 5-12

FERTILITY EFFECT OF CYCAS CIRCINALIS AND IONIDIUM SUFFRUTICOSUM ON DIABETES INDUCED STERILITY OF MALE WISTAR RATS – A HISTOMORPHOMETRIC STUDY

Author: B.Senthil Kumar, J. Vijaya Kumar

Category: Anatomy

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Abstract:

Background: Insulin-dependent diabetes results in hyperglycaemia and production of free radicals which leads to oxidative stress in different tissues. The disturbances of the activity of the reproductive system in diabetes might be due to the influence on Hypothalamo-pituitary-testicular axis.

Aim: To study the fertility effect of the herbs Cycas circinalis and Ionidium suffruticosum in diabetes induced infertile male albino rats.

Materials & Methods: A total of 30 healthy young male albino rats were selected. Diabetes was induced by administration of streptozotocin 50 mg/kg body weight intraperitoneally for 6 weeks. The sterility induced was confirmed by testicular biopsy with histopathological interpretation. Cycas and Ionidium extract 200 mg/kg body weight were administered orally to the experimental albino rats E-1 and E-2 respectively and compared to the positive control albino rats PC which was administered testosterone 10 µg/kg body weight subcutaneously, biweekly with that of the diabetic sterile control rats SC using various parameters such as sexual behaviour, weight of animals, dimension of testes, hormonal and semen analysis, histological and histomorphometry analysis of testes. The drug's efficacy was proved by the restitution of fertility by comparing with the normal fertile control rats NC.

Results: The drug's efficacy was compared by one way ANOVA among the groups and both the herbs showed significant improvement in all the parameters in experimental rats when compared to control rats.

Conclusion: The herbs were found to be more effective on the gonads of diabetes induced sterile male albino rats and it has restituted the fertility back to normal.

Keywords: Cycas circinalis, Ionidium suffruticosum, Sterility, Male infertility, Diabetes

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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