NJBMS - Volume 7, Issue 1, July - September 2016

Pages: 19-25


Author: S.Ravichandran, C.K.VijayaSamundeeswari, Evangeline Jones, Jones Ronald

Category: Biochemistry

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Background : Urolithiasis denotes stones originating anywhere in the urinary tract, including the kidneys and bladder and is a worldwide problem sparing no geographical cultural, or racial groups.Urinary stones usually arise because of the breakdown of a delicate balance between solubility and precipitation of salts.

Aim & Objectives : To analyse 24 hrs urinary citrate, calcium, phosphorous, magnesium & uric acid levels in patients with Urolithiasis.

Methodology : The study consists of fifty patients with evidence of renal stone disease and fifty age and sex matched healthy controls . Subjects for the study were selected from outpatients attending Vinayaka Missions Kirupananda Variyar Medical College & hospital, Salem.,Tamil Nadu . Twenty-four hours urine samples were collected for the analysis of Volume, pH,urinary citrate, calcium, phosphorous, magnesium & uric acid levels.

Results : 24 hours urine volume in cases were significantly lowered when compared to control group. Urine pH in cases (< 5.5) was significantly lowered when compared to control group (> 6). 24 hours Urinary citrate, phosphorous and Magnesium levels were significantly lowered in cases when compared to control groups. Citrate 271.78 ± 26.72 mg/day Vs 739 ± 228.12 mg/day, Magnesium 39.227 ± Vs 116.6 ± 45.74 mg/day. Phosphorous 251.12 ± 29.4 Vs 688.84 ± 162.6 mg/day in cases and controls respectively. 24 hours urinary calcium in control group 170.92 ±35.32 and in cases 291.76 ± 36.03. calcium in cases were significantly higher when compared to control. ( p value < 0.001). 24 hours urinary uric acid in control group 501.68 ±136.79 and in cases 819.66 ± 40.307 . Uric acid in cases were significantly higher when compared to control. ( p value < 0.001).

Conclusion: There was a significant decrease in urinary citrate level in renal stone formers compared to healthy controls, suggesting that hypocitraturia is an important metabolic risk factor for renal stone formation.

Keywords: Urinary citrate, calcium, phosphorous, magnesium, uric acid, Urolithiasis.

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.

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