UA-22728437-71


NJBMS - Volume 7, Issue 1, July - September 2016

Pages: 19-25

ANALYSIS OF 24 HOURS URINARY CITRATE, CALCIUM, PHOSPHOROUS, MAGNESIUM & URIC ACID LEVELS IN PATIENTS WITH UROLITHIASIS

Author: S.Ravichandran, C.K.VijayaSamundeeswari, Evangeline Jones, Jones Ronald

Category: Biochemistry

[Download PDF]

Abstract:

Background : Urolithiasis denotes stones originating anywhere in the urinary tract, including the kidneys and bladder and is a worldwide problem sparing no geographical cultural, or racial groups.Urinary stones usually arise because of the breakdown of a delicate balance between solubility and precipitation of salts.

Aim & Objectives : To analyse 24 hrs urinary citrate, calcium, phosphorous, magnesium & uric acid levels in patients with Urolithiasis.

Methodology : The study consists of fifty patients with evidence of renal stone disease and fifty age and sex matched healthy controls . Subjects for the study were selected from outpatients attending Vinayaka Missions Kirupananda Variyar Medical College & hospital, Salem.,Tamil Nadu . Twenty-four hours urine samples were collected for the analysis of Volume, pH,urinary citrate, calcium, phosphorous, magnesium & uric acid levels.

Results : 24 hours urine volume in cases were significantly lowered when compared to control group. Urine pH in cases (< 5.5) was significantly lowered when compared to control group (> 6). 24 hours Urinary citrate, phosphorous and Magnesium levels were significantly lowered in cases when compared to control groups. Citrate 271.78 ± 26.72 mg/day Vs 739 ± 228.12 mg/day, Magnesium 39.227 ± 4.287.mg/day Vs 116.6 ± 45.74 mg/day. Phosphorous 251.12 ± 29.4 Vs 688.84 ± 162.6 mg/day in cases and controls respectively. 24 hours urinary calcium in control group 170.92 ±35.32 and in cases 291.76 ± 36.03. calcium in cases were significantly higher when compared to control. ( p value < 0.001). 24 hours urinary uric acid in control group 501.68 ±136.79 and in cases 819.66 ± 40.307 . Uric acid in cases were significantly higher when compared to control. ( p value < 0.001).

Conclusion: There was a significant decrease in urinary citrate level in renal stone formers compared to healthy controls, suggesting that hypocitraturia is an important metabolic risk factor for renal stone formation.

Keywords: Urinary citrate, calcium, phosphorous, magnesium, uric acid, Urolithiasis.

No. of online users: 22

Search Articles



Visitor Counter

World wide visitors

News

Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


Indexed in

Index Copernicus (MCI recognized indexing body) ICV - 75.97, Scientific Indexing Services, Research Bib, Indian Science Publication, Eurasian Scientific Journal Index, Science Library Index, International Innovative Journal Impact Factor, Cite Factor, International Impact Factor Service,

Publication Statistics

Articles Statistics

Advertisements

Society for Basic Medical Sciences
NJBMS Journal - Indexed in Index Copernicus

Manuscript Statistics

Subscribe for TOC Alerts

Get the table of contents of current issues.

E-mail Alerts