NJBMS - Volume 7, Issue 2, October - December 2016

Pages: 94-98

Plasma Lipoprotein (a) Levels In Acute Coronary Syndrome At A Tertiary Care Hospital In South India

Author: S. Senthilkumari, M. Ramadevi

Category: Biochemistry

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Background: Increasing prevalence of coronary heart disease (CHD) occurs in Indian population due to rapid changes in demography and life style, consequent to economic development. Prevalence of coronary artery disease (CAD) in south Indians is high compared to north Indians. Investigation in the recent past have suggested that lipoprotein (a) (Lp(a)) concentrations in serum could be a risk factor for occurrence of acute coronary syndrome (ACS).

Aims and objectives: (1) To observe whether Lp(a) is significantly elevated in patients with ACS in comparison to healthy controls (2) To assess association of Lp(a) in ACS.

Materials and methods: 45 cases who were admitted in intensive coronary care unit with clinical findings suggestive of ST segment elevation myocardial infarction (STEMI) (n=35), Non ST segment elevation myocardial infarction (NSTEMI) (n=2) and unstable angina (n=8) were included in the study group. 45 sex and age matched healthy individuals were taken as control group.

Results: Mean plasma Lp(a) levels of study group is higher than that of control group [23.87±7.56mg/dl versus 10.40mg/dl±3.11mg/dl] (p =•000) which is statistically significant. Total cholesterol (TC), triglycerides (TGL), low density lipoprotein (LDL),TC/HDL ratio were statistically high and high density lipoprotein(HDL) was statistically low in study group compared to controls. There is no difference in mean plasma Lp(a) values in males and females in both study and controls.

Conclusion: Increased Lp(a) levels are seen in ACS and is associated with the occurrence of ACS in present study.

Keywords: Acute coronary syndrome, Coronary artery disease, Lipoprotein (a), TC/HDLratio

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.

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