NJBMS - Volume 7, Issue 3, January - March 2017

Pages: 145-152

Association of Plasma Cholesteryl Ester Transfer Protein Activity with Severity of Angiographically Confirmed Coronary Artery Disease

Author: Umamaheswari.V, Veena Juliette.A, Renuka.P

Category: Biochemistry

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Background: Cholesteryl ester transfer protein (CETP), a hydrophobic glycoprotein has a key role in high- density lipoprotein cholesterol (HDL-C) metabolism. It transfers cholesteryl esters from HDL to apolipoprotein-B containing particles in exchange for triglycerides, thereby reducing the concentration of HDL-C and increasing non-HDL-C, a lipoprotein distribution predisposing to atheroma formation. Plasma CETPactivity has been associated with plasma HDL-C concentrations.

Objectives: To determine the association of plasma CETP activity and its associated plasma lipoproteins concentration with angiographically confirmed Coronary artery disease (CAD).

Materials and Methods: In this case-control study, we analysed the plasma CETP activity in 146 patients with angiographically proven Coronary atherosclerosis and 145 non-cardiac cases as control subjects. Plasma CETP activity was determined by fluorometry and serum lipoproteins wereestimated by routine enzymatic end point methods using an autoanalyser.

Results: Patients with CAD had significantly high plasma CETP activity (90.72+15.83pmol/μL/hr) than control subjects (65.23 + 12.23pmol/μL/hr, P=0.000). CAD patients with single, double or triple vessel disease had significantly high CETP activity when compared to control subjects. Significantly lower HDL-C (38.5+9.7 mg/dl versus 48.2+9.9 mg/dL,P=0.000) was observed in Coronary atherosclerosis patients than control subjects.

Conclusion: Our findings indicated that the plasma CETP activity was significantly associated with severity of Coronary artery disease and CETP activity may be an independent risk factor for Coronary atherosclerosis.

Keywords: Cholesteryl ester transfer protein, High density lipoprotein, Coronary artery disease

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.

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