NJBMS - Volume 7, Issue 3, January - March 2017

Pages: 159-163

Study of the Levels of Thyroid Stimulating Hormone and Prolactin in Female Infertility

Author: V.Meera, A.Ellanshivgoutham

Category: Biochemistry

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Introduction: Infertility is defined as the failure of a couple to achieve conception (regardless of cause) after one year of unprotected and adequately timed intercourse. Measurement of prolactin and thyroid hormones, especially thyroid stimulating hormone (TSH), has been considered an important component of infertility work up in women Dyslipidemia and other metabolic syndromes also play an important role in infertility.

Aims and Objectives: To study the levels of thyroid stimulating hormone(TSH) and prolactin(PRL),lipid profile and body mass index(BMI) in infertile women and apparently normal women.

Materials and Methods: A case control study was done at Government Kilpauk Medical College and Hospital and the serum levels of prolactin, total T3(TT3), total T4 (TT4), TSH, lipid profile and BMI were determined in 50 apparently healthy women, 50 infertile women in the age group of 16 to35years. The hormones were assayed using Enzyme Linked Immunosorbent Assay. Lipid profile was estimated by routine methods and BMI was calculated.

Results: There was a significant increase in mean serum prolactin levels of infertile groups when compared to control(40.61±14.48ng/dl vs 16.17 ±10.07 ng/dl) (p=0.001). Increased mean serum Triglyceride, increased BMI, and increased TT3 were observed in infertile group which was statistically not significant. The mean serum TSH, TT4, Total cholesterol(TC), high density lipoprotein(HDL) and age was not different in the infertile women compared to the controls.

Conclusion: Prolactin level was significantly increased in infertile women and estimation of prolactin may be included in the workup for infertile women.

Keywords: TSH, TT3, TT4, Infertility, Prolactin, Lipid profile.

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.

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