UA-22728437-71


NJBMS - Volume 7, Issue 3, January - March 2017

Pages: 164-171

Vimentin Could be a Metastatic Marker in Triple Negative Breast Cancer

Author: Senthil Ponnusamy, Mohammed Naim, Mahboob Hasan, Amanullah Khan, Murad Ahmad

Category: Pathology

[Download PDF]

Abstract:

Bacground : The epithelial-mesenchymal transition (EMT) of the breast carcinoma cells is considered to be an important determinant of aggressive, invasive, and metastatic behaviour of the breast cancer cells. Recent studies showed that Vimentin expression in Triple Negative Breast Carcinoma (TNBC) are associated with poor prognosis and indicates the occurrence of EMT mechanism.

Aim: To study Vimentin expressions in TNBC in females to analyse the diagnostic utility and comparison of the metastatic breast tumor cells with non-metastatic behavior of the breast cancer cells.

Materials & Methods: In this study vimentin expression was studied in 53 cases of TNBC in the North Indian female patients. Sections from the TNBC tumor-blocks were Silver Stain impregnated applying the Gomori's method to find out the integrity of basement membrane in tumor lobules.

Results: Vimentin immune expression score [VIES] in 53 TNBC cases under present study were found to be 47.17%. More than 3/4th (77.78%) cases of metastasizing TNBC showed VIES score of

>30, while it was only 15.4% in non-metastasizing cases and it was found to be highly significant (P value < 0.001)

Conclusion: The vimentin expression in the present TNBC cases demonstrated neoplastic epithelial to mesenchymal cells transformation with significant VIES can be helpful in detection of metastasis.

Keywords: Triple Negative Breast Carcinoma, Epithelial-mesenchymal transformation, Vimentin Immune Expression Score, Vimentin, Metastasis.

No. of online users: 58

Search Articles



Visitor Counter

World wide visitors

News

Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


Indexed in

Index Copernicus (MCI recognized indexing body) ICV - 75.97, Scientific Indexing Services, Research Bib, Indian Science Publication, Eurasian Scientific Journal Index, Science Library Index, International Innovative Journal Impact Factor, Cite Factor, International Impact Factor Service,

Publication Statistics

Articles Statistics

Advertisements

Society for Basic Medical Sciences
NJBMS Journal - Indexed in Index Copernicus

Manuscript Statistics

Subscribe for TOC Alerts

Get the table of contents of current issues.

E-mail Alerts