UA-22728437-71


NJBMS - Volume 2, Issue 1, July - September 2011

Pages: 25-30

COMMERCIAL GRADE MALATHION INDUCED OXIDATIVE IMBALANCE IN MICE: THE ROLE OF ASCORBIC ACID

Author: D' SOUZA R. T. JANITA , BERNHARDT VIDYA , SHANTARAM MANJULA

Category: Microbiology

[Download PDF]

Abstract:

Studies on the ameliorating effects of ascorbic acid on the oxidative imbalance following exposure to commercial grade Malathion (CGM) preparations have not received much attention. The study was designed to understand the effects of ascorbic acid (250 mg/kg) on Swiss Albino mice (weighing 21 – 24 grams and in each group six animals), when three sublethal, subchronic doses of CGM,(50% LD ,25%LD , and5%LD )were administered orally for 14 days. At the end of 14 days the ameliorating effect was checked by estimating the levels of protein carbonyl (PC) in liver, superoxide dismutase (SOD) and catalase (CAT) in the RBCs. In this study, treatment with ascorbic acid showed significant amelioration of altered RBC CAT levels as compared to 5% LD CGM treatment alone. With the dosage of ascorbic acid selected in this study, attenuation of SOD and PC levels which were altered due to exposure to the three doses of CGM and CAT levels which were altered due to 50% and 25% LD CGM was not found to be significant statistically. The dosage of ascorbic acid must be standardized in order to obtain optimum response to satisfy the oxidative changes.

Keywords: Ascorbic acid, catalase, Malathion, oxidative damage, protein carbonyl , superoxide dismutase.

No. of online users: 77

Search Articles



Visitor Counter

World wide visitors

News

Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


Indexed in

Index Copernicus (MCI recognized indexing body) ICV - 75.97, Scientific Indexing Services, Research Bib, Indian Science Publication, Eurasian Scientific Journal Index, Science Library Index, International Innovative Journal Impact Factor, Cite Factor, International Impact Factor Service,

Publication Statistics

Articles Statistics

Advertisements

Society for Basic Medical Sciences
NJBMS Journal - Indexed in Index Copernicus

Manuscript Statistics

Subscribe for TOC Alerts

Get the table of contents of current issues.

E-mail Alerts