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NJBMS - Volume 2, Issue 1, July - September 2011

Pages: 38-42

STUDY TO COMPARE THE CLINICAL EFFICACY OF ORAL THEOPHYLLINE, TIOTROPIUM BROMIDE AND COMBINATION OF FORMOTEROL AND BUDESONIDE IN COPD

Author: KAVITHA RAJARATHNA , SUSHMA M , VIJAYA RAJENDRAN , MURALI MOHAN BV

Category: Pharmacology

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Abstract:

COPD is a progressive disease that is fully not reversible. Drugs are used to prevent exacerbations, to improve the quality of life and slow the progression of the disease. In this randomized double-blinded/ double-dummy, parallel group comparative study involving 60 subjects (of whom 46 completed the trial), a comparison of efficacy (FVC) was made between the most commonly used drugs, theophylline, inhaled tiotropium (DPI), and a combination of formoterol-budesonide by inhaler (DPI). Tiotropium bromide improved FVC significantly. Theophylline also improved the lung function, but was associated with the highest drop-out rate probably due to adverse effects. The formoterol-budesonide combination did not provide statistically significant improvements in FVC. Though the individual drugs did help, it was the combination of all the three drugs that best improved the FVC.

Keywords: COPD, theophylline, inhaled tiotropium (DPI), formoterol-budesonide

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Editor in Chief of NJBMS Dr.Deepti Shastri, Professor and Head, Department of Anatomy, Academic Co-ordinator for Pre and Paraclinical Sciences, VMKV Medical College & Hospital, Salem.


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