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NJBMS - Volume 1, Issue 3, January - March 2011

Pages: 137-141
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BLOOD AND SALIVARY GAMMA GLUTAMYL TRANSFERASE AND OXIDANT-ANTIOXIDANT STATUS IN CHRONIC ALCOHOLICS : A COMPARATIVE AND CORRELATIVE STUDY

Author: Shivashankara A.R. , Susanna TY , Kevin J. Chiramel , Steffy Kuriakose , Malathi M.

Category: Biochemistry

Abstract:

Saliva is an unused or underused diagnostic tool. There is paucity of studies on salivary biochemical changes in alcoholism. There is a need for studies which correlate the biochemical changes in saliva with those of blood. The study aimed to correlate the changes in gammaglutamyl transferase (GGT) and oxidant-antioxidant status in blood and saliva of chronic alcoholics. Blood and saliva samples of chronic alcoholics (n=50) and healthy controls (n=50) were analyzed for GGT, malondialdehyde, GSH, SOD and GST. Statistical significance of the results was evaluated by Student's t test and Karl Pearson Correlation analysis. Activities of GGT in plasma and saliva of alcoholics were higher when compared to controls . Level of GSH and activities of SOD and GST were lower in red blood cells and saliva of chronic alcoholics in comparison to controls. All the results were statistically significant . The direction of change (increase / decrease), was similar in blood and saliva in each biomarker of alcoholism. However, there was no significant correlation between saliva and blood with respect to any of these parameters. Chronic consumption of alcohol led to increased activity of gamma-glutamyl transferase, and oxidative stress indicated by increased lipid peroxidation and decreased antioxidants in blood and saliva. Further studies with large sample size, correlation of alcohol biomarkers of blood and saliva, consideration of all the relevant socio demographic variables and salivary flow rate measurement, are needed