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NJBMS - Volume 5, Issue 2, October - December 2014

Pages: 45-49
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ASSOCIATION OF APOLIPOPROTEIN E POLYMORPHISM AND

LIPID PROFILE IN ESSENTIAL HYPERTENSION

Author: KOMALA GOVINDHARAJULU, PRAGNA B DOLIA

Category: Biochemistry

Abstract:

Hypertension, a state of oxidative stress is associated with nitric oxide(NO) – Angiotensin II imbalance that may be an important component in pathophysiology of hypertension. Recent experimental data suggests marked similarities between the effects of hypertension and hypercholesterolemia, on the arterial intima. Endothelial dysfunction is in the cross road between hypertension and dyslipidemia. Apolipoprotein E(apoE), a polymorphic protein encoded by 3 alleles -  2, 3 & 4, has antioxidant, inhibition of smooth muscle proliferation and lipid peroxidation and NO generating properties in addition to anti-atherogenic effects, which are isoform dependent. In this case - control study, it was proposed to study the association of apoE polymorphism and essential hypertension.

Materials and Methods: The apoE genotyping was done on 155 hypertension patients and 152 controls by polymerase chain reaction and subsequent digestion with Hha1.

Results: Incidence of e4 allele was significantly higher in patients (59.4 %) than in controls (25%; p=0.000). Multiple logistic regression analysis indicated that e4 allele is an independent predictor of HT. The association of apoE polymorphism with lipid levels was well recognized in controls whose total cholesterol and low density lipoprotein cholesterol levels were higher in 4+ allele than in 4 – allele carriers. The odds ratios for 4 and 2 alleles versus 3 allele were 4.79 and 2.08 respectively.

Conclusions: Our study revealed a strong association of the apoE locus with essential hypertension.

Keywords: Angiotensin II, Oxidative stress, Nitric oxide