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NJBMS - Volume 3, Issue 1, July - September 2012

Pages: 27-30
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EVALUATION OF CHEST PAIN IN THE MIDDLE AGED BY RATE PRESSURE PRODUCT ANALYSIS - A RETROSPECTIVE STUDY

Author: RAJESWARI L., GANASHREE C.P., ANITHU C, NATARAJ S M

Category: Physiology

Abstract:

Background: Coronary artery disease (CAD) results from imbalance between oxygen supply and demand of the heart. Myocardial oxygen consumption (MVO2) is a good indicator of the response of the coronary circulation to increased myocardial oxygen demand. Direct measurement of MVO2 is difficult in routine clinical practice but it can be easily calculated by indirect methods like Rate Pressure Product (RPP) analysis. The internal myocardial work performed is represented by RPP and external myocardial work performed is generally expressed as stages of exercise.

Objective of the study: The objective of this study was to study rate pressure product in middle aged with non specific chest pain to isotonic exercise.

Materials and Methods: This is a retrospective cross sectional study carried out in the Department of Medicine, JSS Hospital, Mysore. The study group comprised of 43 patients in the age group of 40-50 years with a history of nonspecific chest pain but normotensive, nondiabetic and with normal resting ECG. Standard Bruce protocol was followed. The patients were divided into two groups - Group A (35 patients with typical angina) and Group B (8 patients with atypical angina). Statistical analysiswasdoneusing SPSSversion 16.

Results: Mean RPP was decreased in patients with atypical angina (Group B) compared to patients with typical angina (Group A) (p < 0.05).

Conclusion: Angina is precipitated by an increase in work of the myocardium to a critical level that is essentially fixed in each patient. This increase in myocardial work is measured by RPP. Most normal individuals develop a RPP of 20 to 35 mm Hg × beats/min × 10-3.

Keywords: Angina, Myocardial oxygen consumption, Rate Pressure Product, Treadmill test.