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NJBMS - Volume 8, Issue 1, July - September 2017

Pages: 16-20
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Study of Serum Magnesium, Calcium, Phosphorous and Alkaline Phosphatase in Chronic Kidney Disease

Author: Nirmala Devi.K, Arshiya Begum.A, Sathiya.K, Deepa Lakshmi.P

Category: Biochemistry

Abstract:

Introduction: Chronic Kidney Disease (CKD) nowadays becomes an emerging condition with increasing morbidity and mortality. It is associated with complex disturbances in calcium, phosphorous, alkaline phosphatase and magnesium levels especially in stage 4 and 5 of CKD.

Aim And Objective: The main aim of this study is to compare the levels of serum, calcium, phosphorous, alkaline phosphatase and magnesium levels in stages 4 and 5of chronic kidney disease patients with healthy individuals.

Materials and Method: About 30 CKD patients in stage 4 and 5, attending Nephrology out- patient department and 30 healthy individuals between the age group 25 to 78 were included in this study, conducted from April to June 2016 at Mahatma Gandhi Memorial Government Hospital, Trichy. Serum levels of Calcium, Phosphorous, Alkaline Phosphatase (ALP) and Magnesium were measured; eGFR was calculated by CKD -EPI Formula. All measured variables were correlated with e GFR and compared between cases and controls.

Statistical Analysis: Statistical analysis is done by SPSS Software.

Results and Conclusion: The results are presented as a mean ± SD and 'p' value of less than 0.05 is considered as significant. In our study, serum Calcium is decreased, serum Magnesium, Phosphorous, Alkaline Phosphatase levels are increased in stage 4 and 5 of CKD (p- value<0.01.Hypocalcemia and hyper phosphatemia due to failing kidney results in secondary hyper parathyroidism in advanced Chronic Kidney Disease, responsible for abnormal mineral metabolism observed in our study.

Keywords: Chronic Kidney Disease, eGFR, Calcium, Magnesium, Phosphorous, Alkaline Phosphatase.