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NJBMS - Volume 8, Issue 3, January - March 2018

Pages: 131-136
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Correlation Between Erythrocyte Malondialdehye Levels and Dyslipidemia in Patients with Type 2 Diabetes Mellitus

Author: Basavaraj Savadi, Nagalakshmi C.S, Prashant G, Rashmi BM, Ganashree CP, Veluri Ganesh

Category: Biochemistry

Abstract:

Introduction: Dyslipidemia is the most common metabolic derangement of diabetes mellitus and is responsible for complications. Long term exposure to high glucose and fatty acid levels can damage the cells by process of oxidative stress. The oxidative stress in (DM) is also aggravated by impairment of the oxidant and antioxidant balance which leads to generation of excess free radicals. These induce membrane lipid peroxidation and generate lipid peroxides, which in turn disintegrates quickly to form reactive carbon compounds. Malondialdehyde (MDA) is such an important reactive carbon compound which is used commonly as an indicator of lipid peroxidation, and it has become an important oxidative stress marker. Majority of previous studies used serum MDA for assessing oxidative stress, but it is less reliable compared to erythrocyte MDA, as they are known to be prone for more oxidative reactions.

Aim and Objectives: The present study was taken to up to evaluate erythrocyte MDAlevels among type 2 diabetic patients as compared to controls and to investigate correlation of erythrocyte MDA levels with lipid profile parameters in type 2 diabetic patients.

Materials and methods: Study included 60 type 2 diabetic patients and 60 healthy controls. Erythrocyte MDA levels and lipid profile parameters was analyzed among the patients and healthy controls by standard laboratory methods.

Results: Serum MDA levels and erythrocyte MDA levels werevery significantly higher in type 2 diabetics as compared to controls(p <0.001). Also, significant positive correlation was obtained between erythrocyte MDA levels and lipid profile parameters other than HDL. Instead, HDL cholesterol exhibited a significant negative correlation (p <0.001).

Conclusion: Based on our study results, it was concluded that poor glycemic control and dyslipidemia in type 2 diabetes mellitus are associated with increased erythrocyte MDA, which is an early marker of lipid peroxidation. This erythrocyte MDA can be used as a potential prognostic marker in prediction of oxidative stress. It has more value when used in diabetic patients with complications, which helps in identifying onset of complications early, thereby improving the quality of life and reducing disease progression.

Keywords: Erythrocyte malondialdehyde, Lipid profile, Type 2 diabetes, Oxidative stress, Lipid peroxidation

DOI: 10.31975/NJBMS.2018.8302

DOI URL: http://dx.doi.org/10.31975/NJBMS.2018.8302