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NJBMS - Volume 9, Issue 3, January - March 2019

Pages: 121-127
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Association of Serum Bilirubin Levels with Cardiometabolic Risk Factors in Maintenance Hemodialysis Patients

Author: R.Sudha , C.K. Vijayasamundeeswari , K.L.Dheepthi , Sivasangari , Jones Ronald

Category: Biochemistry


Background: Cardiovascular diseases (CVD) are the main cause of mortality in end stage renal disease (ESRD) patients. Evidence suggests that total bilirubin levels are associated with the risk of CVD in general population. Higher bilirubin levels are shown to be associated with beneficial effects in Maintenance Hemodialysis (MHD) patients also.

Aims and objectives: 1. To assess the serum bilirubin levels and cardiometabolic risk factors like Body mass index (BMI), blood pressure, lipid profile and fasting blood glucose (FBG) in Maintenance hemodialysis patients. 2. To determine the association between serum bilirubin levels and Cardiometabolic risk factors in these patients.

Materials and Methods: A cross sectional study was carried out in 60 maintenance hemodialysis patients. The patients were analysed for urea, creatinine, fasting blood glucose, lipid profile, and serum bilirubin levels by standard methods. Body mass index, eGFR and blood pressure were recorded. Appropriate statistical analysis was done.

Results: The mean serum total bilirubin levels in MHD patients was 0.7 ± 0.27 mg/dl. Those with lower bilirubin levels had higher FBG, total cholesterol, triglycerides, LDL, urea and lower HDL-C levels.

Conclusion: Bilirubin appears to be a simple and cost effective biomarker indicative of cardiovascular risk in MHD patients. Patients with lower bilirubin levels possibly have increased atherogenic risk for CVD and hence strategies to modify the cardiometabolic risk factors should be sought in these patients with lower circulating total bilirubin levels.

Keywords: Maintenance hemodialysis, Bilirubin, Cardiometabolic risk, Lipid profile

DOI: 10.31975/NJBMS.2019.9303