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      <Volume-Issue>Volume 12, Issue 2</Volume-Issue>
      <Season>October - December 2021</Season>
      <ArticleTitle>LEPTIN- a key player in chronic kidney diseaseLEPTIN- a key player in chronic kidney disease</ArticleTitle>
          <FirstName>Ponnudhali D</FirstName>
      <Abstract>Background: Leptin is an adipose derived protein hormone, involved in body weight regulation. It is found to play an important role in the development of chronic kidney disease (CKD) by various metabolic and inflammatory mechanisms.&#13;
Aim: To assess the serum leptin levels in chronic kidney disease and to analyze its correlation with GFR, BMI, insulin and insulin resistance.&#13;
Materials __ampersandsign methods: Serum leptin and insulin levels were measured in 45 non-diabetic CKD patients (group 1) and 45 healthy controls (group 2). Serum leptin and insulin were measured using DRG __ampersandsign Monobind ELISA kits. HOMA- IR __ampersandsignBMI were calculated and the values taken. The statistical analysisof Independent student t- test __ampersandsign Pearson’s correlation were performed using SPSS 26 software. &#13;
Results:  Serum Leptin levels were significantly increased in group 1 -CKD patients (15.8 ---PlusMinusSymbol--- 2.76ng/ml) compared with group 2 -healthy controls (6.31---PlusMinusSymbol--- 0.87 ng/ml) P=0.003. Serum insulin levels were also significantly increased in the CKD group (14.34 ---PlusMinusSymbol--- 8.23 µU/ml) from that of healthy individuals (6.40 ---PlusMinusSymbol--- 1.16 µU/ml), P= 0.000. There were positive significant correlations of serum leptin with BMI__ampersandsign Insulin (p=0.000)__ampersandsign negative correlation of leptin with GFR.&#13;
Conclusion: Leptin may independently contribute to GFR decline in the kidney and could have a nephrotoxic potential, resulting in CKD.</Abstract>
      <Keywords>Leptin, chronic kidney disease, CKD, leptin resistance, insulin resistance.</Keywords>
        <Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=13723&amp;title=LEPTIN- a key player in chronic kidney diseaseLEPTIN- a key player in chronic kidney disease</Abstract>
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