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NJBMS - Volume 11 Issue 3 , January - March 2021

Pages: 225-233


Brajesh Thankamony 1 , Jesudoss Prabhakaran 2 , Raj Kishore Mahato 3 , J. Mohan

Category: Pharmacology

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Objectives: The objective of this study would be to evaluate rationale use of fixed dose
combinations (FDCs) dispensed in the pharmacy of a tertiary care hospital in Pondicherry.
Materials and Methods: This is a retrospective stud y where 300 prescription copies were
collected, out of which 100 prescription copies containing FDCs was scrutinized in the tertiary
care hospital P.I.M.S Pondicherry. The total number of FDCs were 114, which were taken for
final analysis. FDCs were analyzed for the different pattern of prescribing and rationalism.
Rational use of FDCs was analyzed using WHO seven- point criteria. The data regarding clinical
evidence of safety and efficacy based on the WHO seven - point criteria were analyzed.
Results: Out of 114 FDCs, the most commonly prescribed FDCs were aceclofenac with
paracetomol (19.30%) and amoxicillin with clavulanic acid (14.04%). The females were
prescribed 52.63% of the total FDCs. The FDCs were maximum from the department of
orthopaedics (22.81%), followed by ENT (14.03%) and medicine (12.28%). Out of 114 FDCs,
79% were rational, and only 21% of the FDCs were irrational.
Conclusions: The results of this study clearly demonstrate that majority of FDCs dispensed in
the pharmacy were found to be rationale in accordance with WHO seven- point criteria.

Keywords: Audit, Fixed Drug Combinations


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National Journal of Basis Medical Science / Volume 11 / Issue 3 / 2021 Jan - Mar 232

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Editor in Chief of NJBMS Dr.R. Thamilselvi, Professor and Head, Department of Pathology, VMKV Medical College & Hospital, Salem.

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