Join us   Log in   editor.njbms16@gmail.com  


NJBMS - Volume 11 Issue 3 , January - March 2021

Pages: 225-233

AN AUDIT ON PRESCRIPTION F OR RATIONAL USE OF FIXED DOSE DRUG COMBINATIONS DISPENSED IN THE PHARMACY OF A TERTIARY CARE H OSPITAL

Brajesh Thankamony 1 , Jesudoss Prabhakaran 2 , Raj Kishore Mahato 3 , J. Mohan

Category: Pharmacology

Download PDF

Abstract:

Objectives: The objective of this study would be to evaluate rationale use of fixed dose
combinations (FDCs) dispensed in the pharmacy of a tertiary care hospital in Pondicherry.
Materials and Methods: This is a retrospective stud y where 300 prescription copies were
collected, out of which 100 prescription copies containing FDCs was scrutinized in the tertiary
care hospital P.I.M.S Pondicherry. The total number of FDCs were 114, which were taken for
final analysis. FDCs were analyzed for the different pattern of prescribing and rationalism.
Rational use of FDCs was analyzed using WHO seven- point criteria. The data regarding clinical
evidence of safety and efficacy based on the WHO seven - point criteria were analyzed.
Results: Out of 114 FDCs, the most commonly prescribed FDCs were aceclofenac with
paracetomol (19.30%) and amoxicillin with clavulanic acid (14.04%). The females were
prescribed 52.63% of the total FDCs. The FDCs were maximum from the department of
orthopaedics (22.81%), followed by ENT (14.03%) and medicine (12.28%). Out of 114 FDCs,
79% were rational, and only 21% of the FDCs were irrational.
Conclusions: The results of this study clearly demonstrate that majority of FDCs dispensed in
the pharmacy were found to be rationale in accordance with WHO seven- point criteria.

Keywords: Audit, Fixed Drug Combinations

References:

References:
1. WHO drug information volume 17
[internet ]. Geneva: WHO; 2003.
Available at: http://apps.who.int/medi
cinedocs/en/d/Js4955e/7.html.
2. Baiardini. I, Guerra. L, Pasquali, M,
Bonadonna. P, Pasalaqua. G, Canonica.
G.W. Quality of Life in Patients with
Adverse Reactions to Drugs: Preliminary
Results fro m a New Questionnaire. J
Allergy Clin Immunol 2004; 113(2):
s70.
3. Rayasam SP et al. The irrational fixed
dose combinations in the Indian drug
market: an evaluation of prescribing
pattern using WHO guidelines Int J
Basic Clin Pharmacol. 2013 Aug;
2(4):452- 457.
4. WHO Model List of Essential Medicines
20th List, accessed 5th march 2021,
tions/essentialmedicines/20th_EML2017
.pdf?ua=1>.
5. National List of Essential Medicines
2015, accessed 5th march 2021,
M%2C%202015.pdf>.
6. Neetesh K Jain et al. Rationality of fixed
dose combinations: an indian scenario
The Pharma Research Year: 2009, Vol:
01.
7. Sreedhar D, Manthan DJ, Virendra SL,
Mohapatra S, Ganguly R and Udupa N.
Fixed dose combinations: Ratio nal or
irrational. Current Science 2008; 95(5):
581- 583.
8. Sen A. Indian Market's Fixation with
Fixed Dose Combinations. Rational
Drug Bulletin. 2002, 12 (1): 1 - 2.
Brajesh Thankamony. et al., An audit on prescription for Rational use of Fixed dose drug combinations.

National Journal of Basis Medical Science / Volume 11 / Issue 3 / 2021 Jan - Mar 232

9. ICH E4 Dose response information to
support drug registration
(CPMP/ICH/378/95).
10. Panda J, Tiwa ri P, Uppal R, Evaluation
of the rationality of some FDCs: Focus
on antihypertensive drugs, ‘Indian J
Pharm Sci’, 68, 5, 2006, 647- 648.
11. Kasturi N, Singh S, Ansari KU. An audit
of prescriptions for rational use of fixed-dose drug combinations. Indian J
Phar macol. 1999; 31: 367- 69.
12. Tripathi KD. Essentials of medical
Pharmacology. 6th edition. New Delhi;
Jaypee brothers Medical Publishers (P)
Ltd, 2008.
13. Gautam C S, Aditya S. Irrational drug
combinations: Need to sensitize
undergraduates. Indian J Pharmacol
2006; 38:169- 70
14. Dhaneria SP. Rational and Irrational
Drug Combinations. Drug Bulletin 2010
April; volume 35(2): 1- 15.
15. Balasubramaniam R et al. A Study on
Evaluation of Rationality of Fixed Dose
Combinations. American Journal of
PharmTech Research 2013.
16. Hindoliya M, Sharma PK, Dhaneria SP.
Prescribing Trends of Fixed Dose
Combinations in Teaching and Non
Teaching Hospitals of Ujjain District.
Journal of Pharmacy Research 2012;
Volume 5(7): 3503- 3505.
17. Gautam CS, Aditya S. Irrational drug
combinations: Need to sensitize
undergraduates. Indian J Pharmacol
2006; 38:169- 70.

DOI URL: https://dx.doi.org/10.31975/NJBMS.2020.11301

No. of online users: 16

Search Articles



Visitor Counter

World wide visitors

Flag Counter

News

Editor in Chief of NJBMS Dr.R. Thamilselvi, Professor and Head, Department of Pathology, VMKV Medical College & Hospital, Salem.



Indexed in

Index Copernicus ICV 2018 - 83.64 2017 - 77.14 ICV 2016 - 75.97 ICV 2015 - 57.28 ICV 2014 - 31.13

Coming Soon...

Publication Statistics

Articles Statistics

Advertisements

Society for Basic Medical Sciences

Manuscript Statistics

Subscribe for TOC Alerts

Get the table of contents of current issues.

E-mail Alerts