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NJBMS - Volume 1, Issue 2., October - December 2010

Pages: 76-82
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PHYSIOLOGY OF GLYCOSYLATED HAEMOGLOBIN, AND THE IMPACT OF GLYCAEMIC CONTROL ON LIPID PROFILE IN ADULT MEN WITH TYPE-2 DIABETES MELLITUS

Author: Dr. Yathish .T.R, Dr. Manjula C.G

Category: Physiology

Abstract:

Looking at the effects of insulin deficiency on carbohydrate and lipid metabolism, diabetes mellitus is now being called more a disease of lipid metabolism than carbohydrate metabolism. A cross-sectional study was conducted during March 2005 to March 2006 to study the glycosylated haemoglobin (HbA1c) and lipid levels in normal adults and with type -2 diabetes mellitus and its relation to glycaemic control. Comparison of lipid levels was made between group of diabetic patients and the normals. The lipid fractions i.e. Total cholesterol, triglycerides, and low-density lipoprotein levels of poorly controlled diabetic (HbA1c > 8 %), were respectively higher (p<0.001), (p<0.01) and (p<0.001) than those of the control group. Later the lipid levels decreased drastically with glycaemic control (p>0.05, p>0.05 and p<0.05 respectively). Increased levels of low-density lipoprotein may be a contributory factor to the high risk of atherosclerosis induced coronary artery disease observed in diabetes mellitus patients. Reduction of blood glucose levels is likely to reduce low density lipoprotein levels and the risk of complication, with the lowest risk being in those with glycosylated hemoglobin values in the normal range i.e. less than 8.0%

Keywords: Glycosylated hemoglobin, Glycaemiccontrol, Lipid profile, Type-2 Diabetes Mellitus