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NJBMS - Volume 1, Issue 2., October - December 2010

Pages: 96-98
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CONGENITAL LEUKEMIA IN A NEWBORN WITH DOWN SYNDROME; A CASE REPORT WITH REVIEW OF LITERATURE

Author: Dr. Beere Gowda , Dr. Suresh T.N., Dr. Kiran , Dr. Hemalatha

Category: Pathology

Abstract:

Congenital leukemia is a very rare disorder accounting for less than 1% of all childhood leukemias. Transient Myeloproliferative Disorder (TMD) occurs in 4 to 10% of infants with Down Syndrome (DS) characterized by numerous circulating blast cells and spontaneous resolution within a fewweeks. We present a 3day old male baby with DS presenting with clinical features of shock and high percentage of blast cells in peripheral smear. This case is presented to highlight the clinical and laboratory diagnostic dilemma.

Keywords: Down Syndrome (DS), TransientMyeloproliferative Disorder (TMD), TransientAbnormal Myelopoiesis (TAM), congenitalleukemia (CL)