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NJBMS - Volume 1, Issue 4, April - June 2011

Pages: 217-220
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CYTOLOGY OF BREAST LESIONS – A MORPHOMETRIC APPROACH

Author: R. THAMIL SELVI , P.R. REKHA P.M. SUBRAMANIAM , P.G. KONAPUR , K.R.RAMKUMAR , PAMMY SINHA

Category: Pathology

Abstract:

Aim & Objective;

1. To evaluate the morphometric variation in cytology of breast lesions.

2. To correlate cytologic grade with nuclear morphometry in breast carcinomas.

Methods and Materials :-

A retrospective study of thirty seven patients of breast lesions diagnosed clinically, were sampled for FNAC in the Department of Pathology, Vinayaka Mission's Krubananda variyar Medical College, Salem, from Jan 2008 to Dec 2008. Cases were subclassified as benign and malignant, and those which were malignant cytological Grading and histologic grading were done by Robinson's criteria and Elston's modification of the Bloom- Richardson system respectively. Grading was intern compared with nuclear morphometric studies.

Results:

Our study showed, 9 cases of benign and 15 cases of malignant breast lesions. The mean nuclear diameter were significantly increased from benign to all grades of malignant lesions. However, a good correlation was identified between mean nuclear diameter and pathological tumor grading.

Conclusion

This study suggests that Mean nuclear diameter is an efficient and successful tool distinguishing between benign and malignant lesions. It can be used as a diagnostic tool in "Gray Zone" areas of breast lesions.

Keywords: Fine needle aspiration cytology, CytologicalGrading, Histologic grading and Nuclearmorphometry