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NJBMS - Volume 1, Issue 4, April - June 2011

Pages: 225-228
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EFFICACY AND TOLERABILITY OF TRANDOLAPRIL IN MILD TO MODERATE HYPERTENSION: A DOUBLE BLIND COMPARISON WITH ENALAPRIL

Author: JYOTHI. R PUNDARIKAKSHA. H. P. SRINIVASA PRABHU. N.C. , GIRISH. K VASUNDARA. K , VIJENDRA. R

Category: Pharmacology

Abstract:

Objectives :

To compare the efficacy and tolerability between Trandolapril and Enalapril in mild to moderate hypertension.

Materials & Methods:

This was a prospective, double blind, parallel, comparative clinical trial involving 120 patients with mild to moderate hypertension. Patients were randomized to receive trandolapril 2 to 4 mg once daily and enalapril 5 to 10mg once daily. The participants were followed for 8weeks.

Results:

Both the drugs achieved effective control of blood pressure at the end of 8weeks. The mean reduction in SBP was 22.17 mmHg with trandolapril and 21.47 mmHg with enalapril group; the mean reduction of DBP was 9.57 mmHg with trandolapril and 11.13 mmHg with enalapril. Adverse events were developed in 11 (18.3%) and 12 (20%) patients in trandolapril and enalapril group.

Conclusion:

The efficacy and tolerability of trandolapril was comparable to enalapril in mild to moderate hypertension with minor adverse events.

Keywords: Hypertension; ACEIs; Trandolapril;Enalapril