ASSOCIATION BETWEEN SERUM LEPTIN LEVELS AND HYPERTENSION IN MALES
Author: M. VIJAYALAKSHMI, A.MANAMALLI, G.BHUVANESWARI
Category: Biochemistry
Abstract:
Background: Leptin, an adipocyte-derived hormone, which regulates food intake and energy expenditure acts as a patho physiologic trigger of high blood pressure (BP). Aim: The aim of this study is to evaluate the association of leptin levels with essential hypertension in the non-obese males.
Materials and Methods: The study population includes two groups: Consisting of 50 males with essential hypertension and 39 healthy controls excluding high body mass index (BMI), cardiovascular disease and diabetes mellitus. BP was measured and serum leptin and lipid profile were estimated and compared using Student’s t- test between the two groups.
Results : Cases with high BP had significantly high BMI and leptin levels than healthy controls (p< 0.000 for leptin and < 0.05 for BMI). Multivariate regression analysis showed that leptin was significantly associated with hypertension and not BMI. Conclusion: There is a significant relationship between plasma leptin levels and high BP independent of potential confounders
Keywords: Body mass index, Essential hypertension, Leptin, Renin angiotensin system
