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NJBMS - Volume 4, Issue 4, April - June 2014

Pages: 227-232
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CLINICAL AND ELECTROPHYSIOLOGIC EVALUATION OF PERIPHERAL NEUROPATHY IN HIV INFECTED PATIENTS

Author: B. TAWARE GOVIND, K. TAPADIA JYOTI, M. SABLE PRAKASH, V. BHUTKAR MILIND

Category: Physiology

Abstract:

Background: Peripheral neuropathies are common in patients with human immunodeficiencyt virus (HIV) infection. The most common peripheral neuropathy in the patient of HIV infection is distal symmetric polyneuropathy and inflammatory demyelinating polyneuropathy. Two-thirds of patients with Acquired Immunodeficiency Syndrome may be shown by electrophysiologic studies to have evidence of peripheral nerve disease.

Aim: The aim was to determine motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) in ulnar and median nerves in controls and in HIV infected patients with and without neuropathy and to compare the results obtained. Between these groups.

Material and Methods: Subjects were classified as: Group I - Subjects without HIV infection (control group), Group II –Subjects of HIV without neuropathy and Group III - Subjects of HIV with neuropathy and MNCV and SNCV was determined in ulnar and median nerves bilaterally in all the groups. Each group consisted of 40 subjects in the age group of 20-49 years. Statistical analysis was performed using unpaired t-test after finding mean and standard deviation for each variable.

Results : It was found that MNCV and SNCV was significantly decreased in HIV without neuropathy and HIV with neuropathy patients when compared to normal subjects in ulnar and median nerves. Furthermore, MNCV and SNCV in ulnar and Median nerves was significantly decreased in HIV with neuropathy patients when compared to HIV without neuropathy patients.

Conclusion : The studies of MNCV and SNCV are useful to assess the function of motor and sensory nerve fibres than the clinically demonstrable signs of motor and sensory nerve fibre damage. Thus, it not only helps in early diagnosis of HIV neuropathy, but acts as an adjuvant in the prognosis of HIV neuropathy.

Keywords: Electro diagnosis, Human immunodeficiency virus infection, Motor nerve conduction velocity, Pheripheral neuropathy, Sensory nerve conduction velocity.