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NJBMS - Volume 4, Issue 4, April - June 2014

Pages: 234-238
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COMPARATIVE EVALUATION OF EFFICACY AND TOLERABILITY OF AZITHROMYCIN AND CLINDAMYCIN GEL IN MILD TO MODERATE ACNE VULGARIS

Author: SMITHA RAI, T.N. KUMAR, RAJENDRA OKADE

Category: Pharmacology

Abstract:

Background ; Topical antibotics are preferred for treatment of mild to moderate acne vulguris. As there was the lack of studies comparing azithromycin 2% gel and clindamycin 1% gel in acne vulgaris, this study was teken up.

Materials and Methods : A prospective study was conducted in which patients with mild to moderate acne vulgaris were enrolled. Relevant information on each patient was collected according to the proforma. Patients were advised to apply the test medication over the face, once daily at bedtime. They were followed up every 2weeks, until 8 weeks. At each visit, efficacy of the test medication was assessed by lesion count, Global Clinical Evaluation (GCE), and Patient’s Self-assessment (PSA). Safety of the medications was assessed by Investigator Rated Patient’s Tolerability (IRPT) and adverse effects.

Results : In our study,most of the patients were aged < 20 years and were females. The malar region was the most common site of involvement. Patients receiving azithromycin 2% gel and clindamycin 1% gel showed significant improvement with respect to lesion count, GCE, and PSA. The difference in the improvement in the above paratmeters was found to be statistically insignificant between the two groups. Both the medications were found to be equally safe with the pruritus being more common with azithromycin and burning sensation with clindamycin.

Conclusion : Both azithromycin 2% gel and clindamycin 1% gel are equally efficacious and safe in mild to moderate acne vulgaris.

Keywords: Acne vulgaris, Azithromycin, Clindamycin gel.