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NJBMS - Volume 4, Issue 1, July - September 2013

Pages: 42-46
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ASSOCIATION OF INFLAMMATION AND NUTRITIONAL STATUS IN MAINTENANCE HEMODIALYSIS PATIENTS

Author:

Category: Biochemistry

Abstract:

Background : Malnutrition and inflammation in maintenance hemodialysis (MHD) patients are usually closely associated. Serum C-reactive protein (CRP) and Albumin are acute phase reactants, as well as sensitive and independent markers of inflammation and malnutrition.

Aims and Objectives:

1. To assess the nutritional status of MHD patients by using the Subjective Global Assessment (SGA) score and standard methods (Anthropometric measurements).

2. To find out the association of inflammation (CRP) with nutritional status.

Materials and Methods: 50 End Stage Renal Disease (ESRD) patients, aged 18 – 74 years on MHD were analyzed for serum albumin, CRP, SGA score and demographic & anthropometric data recorded. Appropriate statistical analysis was carried out.

Results : Based on SGA score, 96% of HD patients were found malnourished. SGA score had significant negative correlation ( p < 0 . 001 ) with anthropometric measurements and a weak correlation with serum albumin. 68% of HD patients had a higher range of CRP and CRP showed a significant negative correlation (p<0.05) with serum albumin.

Conclusion : Inflammation likely plays a role in the development of malnutrition in hemodialysis patients. Thereby, a regular nutritional and inflammatory status check is necessary for timely detection and correction of malnutrition.

Keywords: Maintenance hemodialysis, Malnutrition, Inflammation, SGA score, Albumin.