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NJBMS - Volume 6, Issue 4, April - June 2016

Pages: 151-156
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ALTERED CARDIOVASCULAR REACTIVITY IN CHILDREN OF HYPERTENSIVE PARENTS

Author: CHANDAN LALITA M , GULHANE SONALI , BORSE LAXMIKANT J

Category: Physiology

Abstract:

Background: Hypertension is a burning health problem worldwide. It has familial disposition. Stress factor increases risk of essential hypertension especially in offsprings of hypertensive parents. Cardiovascular autonomic reactivity is one of the indicators for prediction of hypertension in future life.

Aims and Objectives: To compare cardiovascular reactivity in normotensive offsprings of hypertensive parents and normotensive parents.

Material and Methods: Study included 100 medical students both male and female between ages 18 to 30 years. During assessment, weight, height, resting heart rate, resting SBP and resting DBP was measured. Change in DBP in isometric handgrip test and cold pressor test, were recorded by automated blood pressure monitor (Omron SEM-1 model, 6607551LF) and Hand-grip dynamometer. Subjects were divided into group I and II and each group contained 50 students with and without history of familial hypertension respectively.

Statistical analysis: Student's unpaired t test was applied for statistical analysis. The outcomes were presented as a mean (SD) and 'p' value of less than 0.05 was considered as significant. Statistical analysis was done using Graph pad Instat 3.0 and SPSS-IS software. Mann-Whitney test used to compare the autonomic function tests.

Result and Conclusion: There was statistically significant (p value < 0.0005) rise in DBP in both isometric handgrip test and cold pressor test showing sympathetic over reactivity especially in young normotensive subjects with hypertensive parents, significant results obtained .The offsprings of hypertensive parents who show higher cardiovascular reactivity, to a stressor given by cold pressor test and isometric handgrip test, is due to sympathetic over reactivity in early life. Purpose of this study is to help in framing guidelines for preventing cardiovascular risk in future for the individuals with hypertensive parents.

Keywords: Cardiovascular reactivity, Hypertensive, Normotensive, Isometric handgrip test, Cold pressor test