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NJBMS - Volume 3, Issue 2, October - December 2012

Pages: 123-126
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HYPOLIPIDEMIC PROPERTIES OF HIBISCUS ROSA SINENSIS FLOWER EXTRACTS IN ALBINO WISTAR RATS

Author: ANUPAM BISWAS, URBAN J.A. D'SOUZA, SHANKAR BHAT, DAMODAR D, SHIVARAJA SHANKARA Y M

Category: Physiology

Abstract:

Background : The use of different parts of medicinal plant to cure specific ailments has been a traditional practice from ancient times. Herbal medicine was a traditional practice, is presently emerging as an alternative medicine since it makes health care affordable for all with scientifically proven properties of cure. Flowers of Hibiscus rosa sinensis (HRS) has been reported in the Indian medicinal literature with beneficial effects in several physiological disorders and were used for their medicinal properties. Hyperlipidemia is a World-wide adverse health problem and most of the antilipidemic drugs have side effects and hence herbal medications were scientifically tried as antilipidemic agents.

Objectives : To evaluate the possible lipid lowering properties of locally grown Hibiscus rosa sinensis flower extracts.

Methods : Male Wistar rats(180-230gm) were divided into seven groups of six each (n=6). The first group was the control. The second, third and fourth groups were given HRS flower extracts orally with the dose level of 80mg/kg, 160mg/kg and 240 mg/kg body weight once a day for 5 days (acute) and fifth, sixth and seventh groups were given same doses of HRS flower extracts for 30 days (chronic). At the end of treatment duration all animals were sacrificed by cervical dislocation. Blood was collected by cardiac puncture and allowed to clot. Serum was separated for the estimation of Total cholesterol (TC), Triglyceride (TG), HDL, LDL, VLDL levels.

Results : Results of different groups were computed and analyzed for assessing the hypolipidemic effects of HRS extracts. There was a decrease in serum cholesterol and triglyceride levels and increase in high density lipoproteins level, in HRS treated groups.

Conclusion : The extract of Hibiscus rosa sinensis possess hypocholesterolemic/hypolipidemic effects

Keywords: Medicinal Plant, alternative medicine, hyperlipidemia, antilipidemic drugs.