FOETO -PLACENTAL WEIGHT RELATIONSHIP IN HYPOSPADIAS CHILDREN AND IN NORMAL CHILDREN WITHOUT HYPOSPADIAS - A COMPARATIVE STUDY
Author: BINDHU.S , PATIL PRAKASH V , NERLI R B , SHANTARAM MANJULA , DHANESH KUMAR KU
Category: Pathology
Abstract:
Hypospadias is a congenital anomaly occurring in male newborn. It is the abnormal opening of the urethra on the ventral surface of the penis, with or without chordee. It is the result of arrested development of urethra, foreskin and ventral aspect of penis for which the only treatment is surgery. The majority of hypospadias are believed to have a multifactorial etiology. Thus, prevention is imperative. To accomplish this, it is necessary to determine the etiology of hypospadias. The association of growth retardation and hypospadias is well established. In addition to many risk factors, lower birthweight has been associated with hypospadias. Another study found that boys with hypospadias have a lower placental weight than normal boys. Fetal testosterone secretion is under the influence of placental human chorionic gonadotropin during first 14 weeks of gestation. The placental insufficiency may disrupt the supply of nutrients and hCG to the fetus leading to growth retardation and hypospadias. To validate this hypothesis, we analyzed all the male infants born at our hospital with or without hypospadias for fetal growth parameters and collected placentas for detailed evaluation. The specific association of fetal weight and placental weight in hypospadias children and in controls seems to be insignificant.
