Evaluation Of Thyroid Function Status In Newly Diagnosed Poly Cystic Ovary Syndrome - An Analysis in a Tertiary Care Hospital
Author: Amirtha Jansirani. R, Ramadevi.K
Category: Biochemistry
Abstract:
Introduction: The most common endocrine disorder in reproductive age group women is Poly cystic ovary syndrome (PCOS) and hypothyroidism. Both these conditions play a vital role in the etiology of Diabetes, coronary artery disease and infertility. Their coexistence increases the morbidity and mortality of each other. Hyperestrogenism has been proposed as one explanation for the occurrence of increased autoimmune disorders like hypothyroidism in females. To determine the prevalence of hypothyroidism among PCOS, a study was conducted among newly diagnosed PCOS patients attending gynaecology outpatient department in a tertiary care hospital.
Aim of the study: To assess the thyroid function status in PCOS patients.
Materials & methods: 73 newly diagnosed PCOS women based on Rotterdam's criteria, were selected. Anthropometric measurements were measured and BMI, waist hip ratio were calculated. Thyroid function status was assessed with Thyroid Stimulating Hormone(TSH). TSH, Fasting Insulin and Total testosterone were estimated with Chemiluminescence Immuno Assay (CLIA) technique.
Results & Discussion: Among them, 21.9% had elevated TSH. The cut-off for diagnosing hypothyroidism was TSH >5µIU/mL. With this, they were divided into two groups. Euthyroid PCOS (Group 1) and Hypothyroid PCOS (Group 2). There was statistically significant difference between the two groups in BMI (P=0.026) and Total testosterone (P=0.023).
Conclusion: The prevalence of hypothyroidism among PCOS women is higher than in general population. This study emphasizes evaluating thyroid function status while treating PCOS women.
Keywords: Hypothyroidism, PCOS, Prevalence of hypothyroidism in Poly cystic ovary syndrome, TSH in PCOS.
