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NJBMS - Volume 7, Issue 3, January - March 2017

Pages: 153-158
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Assessment of Iron Status and Lipid Profile in Type 2 Diabetes Mellitus Patients with Non- Alcoholic Fatty Liver Disease

Author: K.Ponsuganthi, R.Sudha

Category: Biochemistry


Introduction: Non-alcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of the metabolic syndrome which is characterized by obesity, type 2 diabetes mellitus(T2DM), and dyslipidemia, with insulin resistance as a common feature. Lipid peroxidation and iron induced oxidative stress may play a role in NAFLD progression.

Aim and Objectives: 1. To assess the iron status in type 2 DM patients with NAFLD and compare it with T2DM patients without NAFLD. 2. To correlate the serum iron levels with lipid profile and markers of liver injury in T2DM patients with NAFLD.

Materials and Methods: 80 T2DM patients were screened for fatty liver by ultrasonography. Patients without fatty liver were considered as group I and with fatty liver as group II. Serum iron, TIBC, transferrin saturation, fasting blood glucose, AST, ALT, and lipid profile were analysed. Appropriate statistical analysis was done.

Results: Out of 80 Type 2 diabetic patients, 38 (48%) patients had fatty liver. NAFLD patients had significantly (p< 0.05) increased serum iron, triglyceride, total cholesterol, LDL-C, AST and ALT with decreased HDL-C when compared to group I. Fasting blood glucose and TIBC were not significantly different between the groups. Iron had a significant positive correlation with total cholesterol, triglycerides, LDL-C, AST and ALT.

Conclusion: A significantly altered iron status was observed in patients with NAFLD and iron levels were directly associated with the dyslipidemia and the liver enzymes.

Keywords: Serum Iron, NAFLD, Lipid profile, Type 2 Diabetes mellitus.