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NJBMS - Volume 2, Issue 1, July - September 2011

Pages: 43-46
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STUDY OF SICKLE CELL ANEMIA WITH REFERENCE TO PLATELET

AGGREGABILITY AND PLASMA FIBRINOGEN LEVEL

Author: ANITA CHOUDARY, NIGAM RICHA , KANHARE V.V.

Category: Physiology

Abstract:

Sickle cell disease is one of the hereditary haemoglobinopathies with late complications like vasoocclusion crises and multiple organ infarcts which may involve abnormal red cell adherence to endothelium which may be influenced by both RBC and plasma factors

.The present study was under taken to screen mass tribal population to find cases of sickle cell anemia and to determine platelet aggregability and plasma fibrinogen level in sickle cell anemia sufferers. All males in the age group of 7-23 years were divided into two groups based on screening 32 homozygous male with electrophoretic pattern of Hb-S Hb-F and Hb-A selected as study group and 32 normal subjects with pattern Hb-A and Hb-A2.as control group. Screening was done by special test like sickling test and Hb electrophoresis. Platelet agreeability was estimated by 'O' Brien method and Estimation of plasma fibrinogen was done by 'Biuret Method ' Platelet agregability was found to be increased (p<0.05, unpaired T test) and no significant change in plasma fibrinogen level .Increased in platelet aggregability with involvement of plasma factor and low grade activation of haemostatic mechanisms even in the steady state. As platelet and fibrinogen are independent markers of vaso-occlusion and contribute to thrombus formation, which may result in complications in patients suffering fromthe disease.

Keywords: Sickle cell anemia, vaso occlusion, platelet and fibrinogen