Prolactin Level In Women With Fibroadenoma Breast-A Cross Sectional Study
Author: Saravanan. P.S.L, Anu .S
Category: Physiology
Abstract:
Introduction: Prolactin has been proved to be involved in mammary cancer development in humans, but its role in fibroadenoma breast has long been controversial with conflicting reports. Hence this study was done to find out Prolactin level in women with fibroadenoma and if its role in development of tumor is proved, then a feasible drug treatment which could reduce the anxiety and cosmetic problems associated with surgical interventions can be identified.
Objectives:
1. To estimate serum prolactin level in patients with fibroadenoma breast.
2. To compare serum prolactin level of fibroadenoma patients with that of the controls
3. To consider whether prolactin level can be used as an indicator for fibroadenoma breast and has any relation to the disease progression
Materials and methods: A total of 20 female patients between the age group of 18-40 years attending Government Medical College Hospital, Madurai have been studied. Among them 13 patients had fibroadenoma of the breast and 7 normal women served as control. Prolactin level was measured by Immunoradiometric assay.
Results: No significant elevation of prolactin level is seen in women with fibroadenoma breast (mean=25.75ng/ml) when compared with the control and there is no significant association between increased prolactin level and breast fibroadenoma (X2 = 1.83; p = 0.1759).
Conclusion: Prolactin level is not significantly increased in fibroadenoma breast patients. A large scale study is required for a stronger confirmation. Studying the role of locally produced prolactin and mutation in prolactin receptors might help in proper therapeutic management.
