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NJBMS - Volume 8, Issue 4, April - June 2018

Pages: 189-198
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Nipah Virus: A Journey from Bats to Humans

Author: Mathavi Sureshkumar

Category: Microbiology


Nipah virus is a zoonotic virus causing a range of illness from asymptomatic infection to acute respiratory illness ending up in fatal encephalitis. Fruit bats of family Pteropodidae, genus Pteropus acts as natural reservoirs. Nipah virus can be transmitted to humans from animals (bats or pigs) or through contaminated food or directly from human to human. The case fatality is around 40%-75%. There is no specific treatment or vaccines available at present. The primary treatment is supportive. Human monoclonal antibody mAb 102.4 has been successfully tried in humans with no significant adverse effects. This gives promising results as a post-exposure treatment option in future, once the clinical trials are completed.

Keywords: Nipah virus, Pteropus bats, respiratory illness, fatal encephalitis, monoclonal antibody