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NJBMS - Volume 9, Issue 1, July - September 2018

Pages: 27-34
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Clinicopathological Relevance of Volume, Conductivity and Scatter Parameters in Critically Ill Patients

Author: Sudhakar R, Yuva Vishalini R, Kathiresan Jeyashree

Category: Pathology


Introduction : VCS parameters are a part of research population data in automated hematology analysers that are used to calculate differential count . The clinicopathological significance of these parameters at different clinical settings still remain elusive. The purpose of this study was to explain the predictive significance of VCS parameters in critical illness.

Aim and Objectives : To identify VCS parameters and their appropriate cut-off values that predict critical illness, differentiate infectious from non-infectious patients and differentiate gram positive from gram negative infections

Materials and Methods : A total of 556 critically ill patients and 517 controls were enrolled and analysed retrospectively. Test group was subdivided based on primary diagnosis and culture findings. A total of 24 VCS parameters analysed from Beckman LH 750 automated analyser were retrieved for controls and test groups and compared. Similarly, comparison of bacterial infection versus non infections and gram positive versus gram negative infections were done.

Results : VDW-neutrophils with a cut-off of ≥20.17 predicted critical illness with 86% sensitivity and 70% specificity. MNV ≥137.45 highlighted critically ill patients with 83% sensitivity and 70% specificity. VDW-neutrophils ≥ 22.24 and MMV ≥ 161.95 identified patients with bacterial infections. SDW-neutrophils ≥10.72 differentiated patients with gram positive from gram negative infections.

Conclusion : Clinicopathological uses of VCS parameters are multidimensional in predicting critical illness, identifying infectious patients and in differentiating gram positive from gram negative infections.

Keywords: Volume, Conductivity, Scatter, critical illness, infections

DOI: 10.31975/NJBMS.2018.9104